A 750 km ridgeline drive connecting two national parks through the Appalachians — no billboards, no commercial traffic, built purely as a scenic route.
Where Shenandoah National Park's Skyline Drive hands off to the Blue Ridge Parkway proper.
Roughly the midpoint, and worth a night — the Biltmore Estate and a genuinely good food scene.
Gateway to the Great Smoky Mountains, the most-visited national park in the US.